Captain Ahmed Musa and Bright Osayi-Samuel will miss Friday’s AFCON quarterfinal against Angola due to injury.
Turkey-based forward Ahmed Musa injured his thigh in training this week and has since not trained with the rest of the squad.
The 2013 AFCON champion has yet to feature at this AFCON.
His contract at his Turkish club ends this summer.
Fenerbache defender Osayi-Samuel is also out with possibly a knee problem.
He has thus far made two appearances for the Super Eagles in Cote d’Ivoire.
