Rivers United, Plateau United and Kwara United all face a daunting task to make it to the next rounds of the continental cups after they were drawn against tough North African opposition.
In the CAF Champions League, NPFL champions Rivers United will have their work cut out against the current winners of the competition, Wydad Casablanca of Morocco.
Plateau United passage to the second round of the Champions League has another major stumbling block in Tunisian champions Esperance, who have won the continental tournament four times.
Both Rivers United and Plateau United will play the first leg at home, before they travel to North Africa for the return matches.
Kwara United will also have to go past reigning CAF Confederation Cup RS Berkane of Morocco to reach the second round of the competition.
‘The Harmony Boys’ did well to eliminate AS Douanes of Niger Republic 3-0 on aggregate after they won comfortably at their adopted home of Lagos.
They will need another comfortable home win over the African Super Cup winners to stand any chance of staying alive in the Confederation Cup.
The first legs of both competitions will be played between October 7 and 9 with the return legs between October 14 and 16.